Our latest study on CpG island regulation by a novel transcription factor is out in Nature. Using Single-molecule footprinting and interaction proteomics we identified BANP as the protein binding to the so far “orphan” CGCG motif and conferring strong upregulation of linked genes. BANP is an essential gene that opens chromatin upon and positions nucleosomes in CpG islands, but only when its motif is not DNA methylated.